One of the reasons gels such as Estradose and Estragel have caught on is because of concerns over how the most popular drug used for hormone replacement therapy, premarin is obtained from pregnant mares in a way many consider to be cruel and inhumane. Pregnant mares are tethered in stalls for several months with a rubber cup underneath her vulva to collect the urine. The horse will remain in the stable with the cup held in place by overhead support and unable to take more than a few steps, according to the Humane Society's web site. If the tether used to secure the animal in its stall is too short laying down comfortably may not even be possible. Horses that outlive their usefulness as estrogen producers may be euthanized.
Despite the cruelty of how farmers typically obtain premarin, it remains the most popular drug in the United States for hormone replacement therapy. For those with ethical concerns about using the product, several HRT options. Patches such as Estraderm are one option and gels such as Estradose are ways of applying it directly to the skin. Transdermal HRT has the added advantage that unlike pills the substance does not have to be filtered by the body's digestive system. For those who wish to make sure the product goes directly into their blood stream, you can buy estrogen injections which while more invasive typically only have to be taken twice a month.
Premarin will likely remain on the market for a while yet and the conditions for the horses used to produce it will likely be forced to improve by laws similar to the one currently pending to better regulate Pennsylvania's puppy mills. For those taking the drug now who might have found out about some of the problems surrounding it for the first time, it might be time to check into alternate options for hormone replace
Sources:
http://www.hsus.org/pets/issues_affecting_our_pets/equine_protection/the_facts_about_premarin.html
"Hormone Therapy applied in Form of Gel." Dunstan Prial Tuesday, August 23, 2007. The Daily Item. Sunbury, PA
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