Brain Lesions in Neuropsychiatric Disease

In 1981 Dr. Paul Averback reported positive findings in schizophrenia. "... the Nissl substance may not be recognizable in the extreme examples." Averback found "fragmented cellular remnants". He reported "massive distention". "Masses of monomorphic lipid droplet vacuoles" were seen.

Basal Ganglia

The nucleus of the ansae peduncularis is a region of the substantia innominata. The substantia innominata is a group of masses of gray matter. This group is part of the basal ganglia, which consists of cellular masses high in dopamine.

Averback reported positive findings in the NAP (nucleus ansae peduncularis) and the septal areas. The septum is close to the substantia innominata. Both are subcortical (below the cortex).

Fat Droplet Vacuolar Material

It is not completely clear why the lipid droplets exist in schizophrenia, Alzheimer's disease, and Huntington's chorea. They appear to be a biological marker for neuropsychiatric disease.

Buscaino

V.M. Buscaino came after Golgi. Golgi got the Nobel Prize for his drawing of microscopic structures published in his book. Buscaino did not write a book, but he wrote almost countless brilliant scientific papers on schizophrenia. Unfortunately he was unable to come up with a cure for it.

Vito died unfortunately, but his son is carrying his work. This also true of the American Linus Pauling. Linus Pauling Jr. is carrying on his father's work.

The Etiopathogenesis of Schizophrenia

Orlovskaya and co-workers discovered a factor in the blood of schizophrenics which had various effects on rabbits. Serum from schizophrenics was injected into rabbits. The blood glucose of the rabbits went up, presumably due to the toxic protein factor. The unknown factor appears to be causing a kind of diabetic state which may not be the same as the usual diabetes. It appears to inhibit glycolysis.

Website

More information on these matters is presented on my website, which is http://www.craigolson.bizhosting.com/. A strict vegan diet is recommended because amino acids are flooding the cells. This is why the glucose metabolism is slowed. The brain is burning amino acids instead of glucose.

Interpretation

It may be possible to cure, or at least greatly alleviate, several major diseases. These include schizophrenia, depression, obsessive-compulsive disorder, panic disorder, autism, Alzheimer's disease, Huntington's chorea, ADHD, and others. The reason why this is the case is that it appears that these diseases all involve disorders in amino acid metabolism. Amino acids are found in the brain and in the diet.

Amino Acids in Psychiatry

Even though there is great hope, there are also murky waters. In addition to the great complexity of the human brain, there are also problems of political censorship and resistance to new ideas. Linus Pauling ran up against these problems and was largely defeated by them.

Nevertheless, Pauling planted a seed which began to grow.

Pauling's first paper on the subject appeared in 1968. In 1987 a report by Italian workers was published. Like Pauling, Smeraldi et al believed that schizophrenia was genetic. They found amino acid disorders "in schizophrenic patients". They found "increased concentrations of various amino acids in schizophrenic patients". Thus the Italian theory was more specific than the theories of Pauling. Pauling favored altering the molecular environment of the mind.

Certain amino acid disorders "are associated with schizophrenia-like psychotic disorders, for example, hyperasparaginemia and homocystinuria".

Conclusions

Because of the tremendous importance and complexity of these matters, this article will be continued in the future. It will probably have to be sent in several parts to do justice to the subject. For more information, consult the bibliography.

Bibliography

1. www.associatedcontent.com/article/723727/an_endogenous_inhibitor_of_monoamine.html
2. www.associatedcontent.com/article/734885/toxic_factors_in_schizophrenia.html
3. www.associatedcontent.com/article/735051/the_microscopy_of_schizophrenia.html

4. www.associatedcontent.com/article/733043/schizophrenia_as_an_error_in_evolution.html
5. www.associatedcontent.com/article/736707/biochemistry_and_schizophrenia.html