Flushing with Niacin: Why Does it Occur?
Flushing with Niacin: Why Does It Happen?
It's not completely clear why flushing with niacin occurs, but there are some hypotheses. When niacin is taken at doses high enough to lower cholesterol it causes natural chemicals called prostaglandins to be produced. When these prostaglandins are released into the bloodstream, blood vessels dilate which leads to flushing of the skin. A chemical called histamine is also released which causes symptoms such as itching and tingling. In many people the symptoms are so distressing that they stop taking niacin before it has a chance to lower their cholesterol. Fortunately, the body develops tolerance to niacin and the symptoms become less pronounced over time.
Is There Any Way to Prevent Flushing with Niacin?
One way to reduce niacin flushing is to take one of the newer extended release niacin formulations. Although this can significantly reduce the uncomfortable flushing symptoms, it also increases the risk of liver toxicity and should only be used under close medical supervision. Taking an aspirin thirty minutes before niacin also helps to reduce flushing and itching. This only works if you take a full strength 325 milligram aspirin rather than a 80 milligram baby aspirin. It's also important to avoid drinking hot drinks or alcohol within an hour of taking a niacin pill.
Flushing with Niacin: The Bottom Line?
Niacin is effective at lowering LDL and raising HDL cholesterol levels, but flushing can be a problem. Fortunately, flushing with niacin lessens over time and can be reduced by using extended release niacin and taking an aspirin before each dose. Niacin should only be used under the care of a doctor where blood tests can be used to check liver function regularly. If you have a high cholesterol, talk to your doctor about whether niacin is right for you.
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Published by Kristie Leong M.D. - Featured Contributor in Health & Wellness
I'm a family physician with a strong interest in disease prevention and alternative medicine. I'm particularly interested in how diet plays a role in disease prevention. Hope I can inspire someone to lead a... View profile
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