Number One Seeds Favored in Opening NCAA Tournament Games

As budding "bracketologists" busily weigh in their picks for their annual March Madness office pool, what number one seed has the best chance of winning the NCAA Tournament?

Connecticut, Louisville, North Carolina and Pittsburgh are all favored number one seeds in this years tourney. As one would expect, all four of the top seeds are all heavy favorites in their opening-round games.

Big East champion Louisville (28-5), the No. 1 seed both overall and in the Midwest Region, will play their first game on Friday against Morehead State. Louisville gave Morehead State a walloping the last time the two teams met beating them by 38 last November.

The North Carolina Tar Heels (28-34) are the No 1 seed in the south region and earned the top spot after an ACC title victory 73-70 over Florida State. The Tar Heels the No. 1 seed are a 27.5-point favorite - the largest spread of the first round - against the Radford Highlanders in their opening game on Thursday.

Connecticut, the No. 1 seed in the west region, is favored by 21.5 against the Tennessee Mocs in their opening game. The Huskies are currently 3 for 5 in their last 5, losing to Syracuse 127-117 in the Big East Conference Tournament.

In the east region it's all about the Pittsburgh Panthers (28-4). The Panthers got the top seed after going 10 for 11 to wrap up the regular season and then losing to West Virginia in the Big East Conference Tournament. The East regional's No. 1 seed, are 21.5-point faves over the East Tennessee State Bucs.

If the top four seeds all make it to the Final Four, Louisville would take on Connecticut and Pittsburgh would face North Carolina.

The Cardinals who are a 10 game win streak and could be very dangerous to the favored North Carolina Tar Heels if they meet anywhere along the way.

The NCAA National Championship game is slated for April 6 at Ford Field in Detroit.