SAM-e for Depression, Arthritis & More

Found in every cell in your body, SAM-e, or S-adenosyl-methionine, is natural compound made from the amino acid methionine. In the body, SAM-e is an important part of several natural chemical processes, including the production of neurotransmitters like dopamine and serotonin.

As a supplement, SAM-e can be an effective natural remedy for osteoarthritis and the pain, stiffness and swelling that often accompanies it. SAM-e is also the subject of a growing library of studies looking at depression and other mood disorders.

Less-studied is SAM-e's potential use in the treatment of a wide variety of other conditions including fibromyalgia, certain liver conditions, some AIDs-related issues and even adult ADHD.

How To Take SAM-e

In North America, most SAM-e is packaged in 100, 200 or 400 mg. doses. Typically, SAM-e is taken twice a day. And because SAM-e is absorbed in the intestine and not the stomach, it's important to look for a SAM-e supplement with an enteric coating. Enteric-coated capsules may also be less likely to cause stomach upset and nausea, two of the most common side effects of SAM-e.

Finding Quality SAM-e Supplements

SAM-e tends to rather expensive; a month's supply of this supplement can run $60 or more, depending on the dosage you use. Obviously, getting your money's worth is important, especially since SAM-e is marketed as a nutritional supplement and not as an over-the-counter drug. The good news is that a 2007 test of 10 brands of SAM-e resulted in "Approved" ratings for all 10 brands. Quality SAM-e products are now readily available at pharmacies, supermarkets and even discount department stores.

Is SAM-e Right For You?

SAM-e is generally considered safe for most people. Side effects are usually mild and include nausea or upset stomach.

One group that definitely shouldn't take SAM-e includes people with bipolar disorder. In open trials, SAM-e triggered manic states in some test subjects. And SAM-e may not be appropriate for people taking MAO inhibitors, SSRIs or tricyclics. It's also important to note that SAM-e has not been established safe for young children, people with severe liver or kidney disease and women who are pregnant or nursing.

Ultimately, though, the only person who can tell you if SAM-e is appropriate for you is your doctor. If you have any questions about SAM-e, talk to your primary health care provider for the information that's right for you.

REFERENCES:

Carney, M., Chary, T., Bottiglieri, T., Reynolds, E. (1989). The switch mechanism and the bipolar/unipolar dichotomy.

di Padova, C. (1987). S-adenosylmethionine in the treatment of osteoarthritis. Review of the clinical studies.

Bressa, G., (1994). S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies.