Too Many Amino Acids Flood the Brain in Schizophrenia

Tikhonov et al of the Soviet Union found a beta-2-globulin that increased membrane permeability. A similar report appeared by Romasenko, also of the Soviet Union.

Tikhonov, Lozovsky, & Glezer (1967)

This brilliant Russian group studied rat brain slices incubated with blood serum from schizophrenics. They reported the membrane of the mitochondria showed swelling and fragmentation.

Romasenko (1967)

Romasenko showed a deterioration in the membranes of both cells and mitochondria. Thus there appears to be a membranolytic substance in the serum of patients with schizophrenia.

Gerber & Nikolaeva (1968)

These Russian scientists reported a study on rats. Previously (1966) they and Romasenko reported a study on rabbits. In the newer study they used 42 rats.

They injected the rats with serum. The results were finely vacuolized cytoplasm, sharply hyperchromic cell, etc. "In places, only shapeless residues of such honeycombed cells were found. In basophils cytoplasmic degranulation was seen. This might mean destruction of the Nissl bodies.

"Lipid droplets were mainly finely dispersed."

"From time to time, basophils lost granules, and their protoplasm became lighter." What was then called "protoplasm" is now called "cytoplasm".

Chronic Schizophrenia

Rats were studied which received serum, from patients with chronic schizophrenia.

"In all cases dystrophic changes, in the form of fine, cytoplasmic vacuolation, were pronounced." There were "shadow cells" in which"sometimes structureless fragments of finely vacuolized cytoplasm" were seen. This was observed in the hypothalamus.

In the pituitary glands "all cases" showed "signs of dystrophy". There was "a multitude of diffuse, finely vacuolized cells". This is consistent with the work of the Vogts on human brains. The Vogts also reported vacuolized cytoplasm.

"Sudanophilia was pronounced ..." This means fat because fat stains with the Sudan chemical.

Conclusions

The Russian scientists concluded that the morphology was consistent with "a fear reaction". Rats in the third group (chronic schizophrenia) had "sharply pronounced dystrophic changes". This disproves the popular neurodevelopmental theory of schizophrenia.

The pituitary and the adrenals showed "reaction in response to stress". There were "severe, even leathal, dystrophic changes in neurosecretory cells."

The results are consistent with my theory of amino acids flooding the cells. Some excess amino acids would be converted to fat. Thus the fat droplets are explained. If this theory is true, a diet very low in amino acids is suggested.

Fruits are very low in both amino acids and fats. The diet that I am proposing is very high in fruit.