Why Does Ovarian Cancer Suppress Appetite?

Ovarian cancer can suppress appetite; this is a hallmark feature of this disease, the deadliest of all gynecological malignancies. I was wondering just what mechanisms are involved that make ovarian cancer lead to appetite suppression.

I consulted with Diane Yamada, MD, Chief, Gynecologic Oncology, University of Chicago Medical Center. First of all, realize that if you've had a suppressed appetite lately, don't torture yourself by jumping to the conclusion that you probably have ovarian cancer, which is very rare in premenopausal women.

Dr. Yamada explains, "Advanced ovarian cancer can sit on the surface of the stomach or the intestines and this can make the patient feel full early. Tumors, extensively involving the omentum, known as an 'omental cake,' can also make the patient feel full all the time." The omentum is a fold in the abdominal cavity connecting the stomach to other organs.

Dr. Yamada continues, "This full sensation, called 'early satiety,' may suppress the patient's appetite. Ascites fluid can also make the patient feel constantly full, which can suppress the appetite." In the case of ascites, which can result from ovarian cancer (and other malignancies
such as pancreatic), and non-malignant disease processes such as cirrhosis of the liver, up to two liters of fluid may be present, suppressing appetite, causing a bloating feeling, and creating visible distention of the abdomen.

"In advanced and recurrent ovarian cancer," continues Dr. Yamada, "Tumors can also cause a bowel blockage or obstruction, which may make the patient feel nauseous and not want to eat."

Thus, once ovarian cancer begins causing suppression of appetite, the disease may very well have already spread beyond these walnut-sized organs, into the abdominal area.

Survival rates for OC are dismal because usually, this disease is discovered after it has spread. This is because there are no screening methods for detection. If you're wondering about ultrasound, this tool cannot create an image definitive enough to differentiate between a malignant and a benign mass. Neither can an MRI or CAT scan. A confirmed diagnosis is made via biopsy (tissue is removed surgically).

Only 19 percent of cases are discovered while the disease is still localized to the ovaries. These discoveries are made incidentally from imaging tests that the patient receives for other reasons, such as a pregnancy checkup, or X ray of the pelvic area after a car accident. A "suspicious" mass is detected, and diagnostic follow-up reveals malignancy. However, such masses aren't always malignant, either (e.g., benign cysts). Surgery (biopsy) confirms OC diagnosis.

68 percent of cases are discovered after the disease has spread to other organs. Five-year survival rate for localized disease is 93 percent, and for metastases to distant sites is 29 percent.

Again, if you have appetite suppression, don't lose sleep thinking it might be ovarian cancer. Appetite suppression has a myriad of causes, including the fear that you might have ovarian cancer! You then read up about symptoms and discover that appetite suppression is one of them; suddenly, you can't eat! Anxiety kills appetite.

Source: http://ovarian-cancer.emedtv.com/ovarian-cancer/ovarian-cancer-survival-rate-p2.html