Dr. Abram Hoffer
Introduction
In an effort to avoid using the same title twice, I decided to include the rare term "psychodietetics" in my titles. This term appears to have been invented by Dr. Cheraskin, an orthomolecular doctor.
Lavoisier
"It took them only an instant to cut off that head, and a hundred years may not produce another like it." Joseph-Louis Lagrange (noted mathematician)
Lavoisier was a brilliant French scientist who was guillotined in the French Revolution. he studied how the body metabolizes food to create energy. My opwn theory is that something goes wrong in this process in the brain in mental illness. Something also goes wrong in diabetes.
Soviet Work
Orlovskaya, Savulev, and Oifa (1978) reported "acute swelling" of neurons in schizophrenia using the electron microscope. Kleshchinov & Oifa (1986) reported "swelling of cysterns of the endoplasmic reticulum and loss of polysomes" in schizophrenia. This would probably happen if the cells were being flooded with amino acids. The cysterns house amino acids. They reported "cytoplams lightening".
Bonartsev (1976) reported activated lymphocytes. Bonartsev confirmed this in a 1977 study.
Orlovskaya, who is still doing research today, found "disappearance of cells, lipoid deposition, acute swelling, karyocytolysis" etc. Acute swelling would be explained if amino acids were flooding the cells.
British Research on Mental Science
A British group, Tyrrell et al, reported "enlarged mitochondria with few cristae". They found a toxic factor in the cerebrospinal fluid of schizophrenics and patients with Huntington's chorea. The factor from the two diseases appeared to be the same. They tested it for a virus, but all tests for a virus failed. They could not passage the toxic factor. They could not infect another culture.
They added the toxin to cells in a culture, and the cells were damaged. The factor was "cytopathic".
Since amino acids can enter the mitochondria, these results are consistent with the theory of amino acids flooding the cells.
The Weil Thing
Dr. Andrew Weil has favored "optimum health", "integrative medicine", and "healthy aging". His book "Healthy Aging", one of many of his books, was published in 2005. By "integrative medicine", he means that he accepts both alternative medicine and orthodox medicine, much like myself. I reject certain things in orthodox medicine and certain things from alternative medicine that I feel are quackery. The quackery in orthodox medicine is more dangerous because it often involves drugs. Medication errors can and have caused deaths. I accepot those things in orthodox medicine that are legitimate, and I also accept those things in alternative medicine, such as nutrition, that I feel are scientific.
"Note that the widely prescribed statin drugs inhibit the body's own production of this compound; anyone on a statin should be taking supplemental Co-Q-10." Weil
Weil's diet is "rich in flavonoids from tea, berries, and other fruits, vegetables, and dark chocolate". Here we differ a little. I do not eat chocolate because it contains caffeine. There is a theory that caffeine can aggravate the prostate. There is also a theory that caffeine makes you hyper. There is also a theory that caffeine contributes to pruritis ani, which means anal itching.
Weil feels that there are "immune-enhancing mushrooms" including shiitake, maitake, and oyster mushrooms. He has been influenced by Oriental medicine. I have also been influenced by some Japanese theories.
Conclusions
"It is not ... that some people do not know what to do with the truth when it is offered them, but the tragic fate is to reach, after patient search, a condition of mind-blindness, in which the truth is not recognized, though it stares you in the face."
Sir William Osler, physician (1849-1919)
But what is the truth that is staring us right in the face? The truth is that mental diseases are caused by amino acids flooding the brain cells. This situation is caused by a toxic factor in the blood. More information on this is given in the references, particularly those written by Moscow workers (Orlovskaya, Uranova, etc.). The Moscow neuropathologists have repeatedly proven that schizophrenia is organic and that it is in the brain. Orlovskaya has been writing these reports since the Sixties, and she is still actively researching. In my opinion she should have won a Nobel prize by now, but she hasn't. This may be because psychiatry has been viewed as murky waters.
Some consider psychiatry to be the retarded child of medicine. I plan to write future articles about the toxin that causes schizophrenia. There are biochemical tests for schizophrenia, but these are controversial due to the prejudice against them. Many still cling to the false view that schizophrenia has no organic basis.
References
1. Emanuel Cheraskin "Disease Continuum: Let's focus on health, not labels". Nutrition Health Review. . FindArticles.com. 04 Jan. 2009. http://findarticles.com/p/articles/mi_m0876/is_1997_Wntr/ai_57230909
2. Hoffer A & Osmond H (1961) Double blind clinical trials. J Neuropath 2: 221-227.
3. Sommer R and Osmond H. (1960) Autobiographies of former mental patients. Journal of Mental Science 107:648-662.
4. Hoffer A & Osmond H (1961) The biochemistry of mental disease. Can Med Ass J 85:1309-1311.
5. www.associatedcontent.com/article/1333742/neurobiological_disturbances_in_schizophrenia.html
6. www.associatedcontent.com/article/1330527/advances_in_brain_research.html
7. www.associatedcontent.com/article/1327509/brain_abnormalities_in_mental_diseases.html
8. www.associatedcontent.com/article/1321835/dont_get_depressed_about_schizophrenia.html
9. www.associatedcontent.com/article/1318766/brilliant_russian_medical_research.html
10. Osmond H & Hoffer A (1961) A brief account of the Saskatchewan research in psychiatry. J Neuropsychiatry 2: 287-291.
11. Hoffer A & Osmond H (1962) Some schizophrenic recoveries. Dis Nerv Syst 23: 204-210.
12. Uranova N, Orlovskaya D, Vikhreva O, et al. Electron microscopy
of oligodendroglia in severe mental illness. Brain
Res Bull. 2001;55:597-610.
13. Uranova NA, Vostrikov VM, Orlovskaya DD, Rachmanova
VI. Oligodendroglial density in the prefrontal cortex
in schizophrenia and mood disorders: a study from the
Stanley Neuropathology Consortium. Schizophr Res. 2004;67:
269-275.
14. Kolomeets NS, Orlovskaya DD, Rachmanova VI, Uranova NA. Ultrastructural alterations in hippocampal mossy fiber synapses in schizophrenia: a postmortem morphometric study. Synapse . 2005 Jul 1 ; 57(1):47-55.
15. Natalya A. Uranova, Victor M. Vostrikov, Olga V. Vikhreva, Ivetta S. Zimina, Natalya S. Kolomeets and Diana D. Orlovskaya (2007). The role of oligodendrocyte pathology in schizophrenia. The International Journal of Neuropsychopharmacology, 10 , pp 537-545
doi:10.1017/S1461145707007626
16. Schultz SK, Andreasen NC: Schizophrenia. Lancet 1999; 353:1425-1430.
17. Uranova NA, Orlovskaya DD: Ultrastructural pathology of neuronal connectivity in postmortem brains of schizophrenic patients, in Annals of Psychiatry: Basic and Clinical Neurosciences, vol 6. Edited by Cacabelos R. Barcelona, Prous Science, 1996, pp 55-72.
18. Biomarker discovery in psychiatric disorders.
Schwarz E, Bahn S.
Electrophoresis. 2008 Jul;29(13):2884-90.
Published by Craig Olson
I have worked at many different jobs including as a scientist, a mental health worker, a physical health worker, etc. I am an advocate for better health care and an advocate for the disabled. View profile
- Justifications for the Amino Acid Theory of Schizophrenia My theory is that amino acids flood the brain in psychiatric disorders. This is why glucose metabolism is slow. The brain is burning the amino acids for fuel.
- The Microscopy of Schizophrenia Many positive findings have been reported in schizophrenia. I have formulated a theory of amino acids flooding the cells.
- The Link Between Food Allergies and Mental Illness Some orthomolecular theories of mental illness involve food allergies. My own theory is that there is an allergic reaction to protein because too many amino acids are flooding the cells.
- The Scientific Study of Schizophrenia and a Solution Schizophrenia is caused by a toxin which makes amino acids flood the cells. A strict diet is recommended.
- Correcting the Biochemical Errors in Schizophrenia and Depression It appears that amino acids are flooding the brain cells in these diseases. No drug has been devised to correct this problem. A diet is suggested.
- European Psychiatry Research
- Too Many Amino Acids Flood the Brain in Schizophrenia
- The Molecular and Cellular Pathology of Schizophrenia
- The Autointoxication Theory of Schizophrenia
- Amino Acids: Why All the Fuss?
- Amino Acids and Health
- Dopamine, Amino Acids, and Schizophrenia